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How to Travel from

Melipilla to La Serena

by Route or Car

Melipilla
→
+0 →
La Serena
Transport search to La Serena
Simply select points
A and B, and we will create
a convenient route for you 👍
Chile Melipilla La Serena
Melipilla
→
+0 →
La Serena
Building a composite car route
Simply select points
A and B, and we will create
a convenient route for you 👍
To build a composite route, click the "Add point" button.
You can also move and delete intermediate points.
Cheapest
Best Offer!
Car
5 h 14 min
541 km.
from $29
Composite Route Car Only
Schedule

Melipilla, Chile → La Serena, Chile

All
31 juil. 2026
July 2026
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Cheapest and Fastest Ways to Travel from Melipilla to La Serena

Composite routes from Melipilla to La Serena

Cheapest
5 h 14 min
Car
541 km.
from $29
Other
4 h 3 min
Bus, Plane
420 km.
from $106.37
7 h 17 min
420 km.
from $30.50
7 h 43 min
420 km.
from $24.43
7 h 55 min
420 km.
from $12.74

Transport providers

Airlines

JetSMART

Website:
jetsmart.com/
Plane from Comodoro Arturo Merino Benítez International Airport to La
Ave. Duration:
1h 10m
Frequency:
Every day
Estimated price:
$26.09–$119.57

Sky Airline

Website:
skyairline.com/
Plane from Comodoro Arturo Merino Benítez International Airport to La
Ave. Duration:
1h 7m
Frequency:
Every day
Estimated price:
$20.65–$119.57

LATAM Chile

Website:
latam.com/
Plane from Comodoro Arturo Merino Benítez International Airport to La
Ave. Duration:
1h 7m
Frequency:
Every day
Estimated price:
$26.09–$119.57

Bus operators

Pullman Bus

Phone:
+56 600 600 0018
Email:
clientes@pullmanbus.cl
Website:
pullmanbus.cl
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 20m
Frequency:
Hourly
Estimated price:
$25.00–$34.78

Flixbus Chile

Website:
flixbus.com
Bus from Terminal San Borja to Terminal
Ave. Duration:
5h 55m
Frequency:
Twice daily
Estimated price:
$8.15–$10.87
Bus from Santiago to La
Ave. Duration:
5h 20m
Frequency:
Twice daily
Estimated price:
$8.15–$10.33

Turbus

Phone:
+56 22 822 7500
Email:
atencion_clientes@turbus.cl
Website:
turbus.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 40m
Frequency:
Hourly
Estimated price:
$15.22–$39.13
Bus from Terminal Alameda - Turbus to Terminal
Ave. Duration:
6h 10m
Frequency:
Hourly
Estimated price:
$15.22–$40.22

Pullman San Andrés

Email:
contacto@transportestransmat.cl
Website:
pullmansanandres.cl/
Bus from Terminal Alameda - Turbus to Terminal
Ave. Duration:
6h
Frequency:
5 times a day
Estimated price:
$17.39–$26.09

Condor Bus

Phone:
+56 22 822 7528
Email:
clientescondor@condorbus.cl
Website:
condorbus.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 50m
Frequency:
4 times a day
Estimated price:
$14.13–$27.17
Bus from Terminal Alameda - Turbus to Terminal
Ave. Duration:
6h 20m
Frequency:
4 times a day
Estimated price:
$15.22–$28.26

Andimar

Phone:
+56 22 683 8528
Email:
hola@andimar.cl
Website:
andimar.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 10m
Frequency:
Hourly
Estimated price:
$9.78–$23.91

Ramos Cholele

Phone:
+56 57 226 9210
Email:
consultas@ramoscholele.cl
Website:
busesramoscholele.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
5h 30m
Frequency:
Twice daily
Estimated price:
$9.78–$10.87

Expreso Norte

Phone:
+56 2 3304 8632
Website:
expresonorte.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 20m
Frequency:
Twice daily
Estimated price:
$10.47–$20.65

Pluss Chile

Phone:
+56 22 3813 550
Email:
info@plusschile.cl
Website:
plusschile.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 30m
Frequency:
Hourly
Estimated price:
$10.77–$22.83

Ciktur

Phone:
+56 9 8880 0397
Email:
contacto@ciktur.cl
Website:
ciktur.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 50m
Frequency:
3 times a day
Estimated price:
$13.04–$33.70

Buses Romani

Phone:
+56 51 221 5300
Email:
atencionalcliente@romani.cl
Website:
busesromani.cl/
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h 30m
Frequency:
Every 4 hours
Estimated price:
$15.22–$19.57

Buses Serena Mar

Phone:
+56 94 915 6683
Website:
kupos.cl/es/pasajes/bus/serena-mar
Bus from Terminal San Borja to Terminal
Ave. Duration:
6h
Frequency:
Twice daily
Estimated price:
$11.96–$19.57

Buses Jimenez

Phone:
+56947968400
Website:
facebook.com/buses.jimenez
Bus from Terminal de Buses de Melipilla to Terminal
Ave. Duration:
1h
Frequency:
Twice daily
Estimated price:
$1.41–$1.96

Ruta Bus 78

Phone:
+56 44 369 9457
Email:
info@rutabus78.cl
Website:
rutabus78.cl/
Bus from Terminal de Buses de Melipilla to Terminal
Ave. Duration:
1h 34m
Frequency:
3 times a day

Buses Melipilla Santiago

Phone:
+56 2 2832 3801
Website:
chilepasajes.cl/es/buses/buses-melipilla-santiago
Bus from Terminal de Buses de Melipilla to Terminal
Ave. Duration:
1h
Frequency:
Every 15 minutes
Estimated price:
$2.73

Questions and Answers

What is the cheapest way to get from Melipilla to La Serena?

The cheapest way to get from Melipilla to La Serena is to bus via Quilicura which costs $10.87 - $15.22 and takes 7h 55m.

What is the fastest way to get from Melipilla to La Serena?

The fastest way to get from Melipilla to La Serena is to bus and fly which takes 4h 3m and costs $48.91 - $119.57 .

Is there a direct bus between Melipilla and La Serena?

No, there is no direct bus from Melipilla to La Serena. However, there are services departing from Terminal de Buses de Melipilla and arriving at Terminal de Buses La Serena via Terminal San Borja. The journey, including transfers, takes approximately 7h 17m.

How far is it from Melipilla to La Serena?

The distance between Melipilla and La Serena is 483 km. The road distance is 541.8 km.

How do I travel from Melipilla to La Serena without a car?

The best way to get from Melipilla to La Serena without a car is to bus which takes 7h 17m and costs $9.24 - $42.39 .

How long does it take to get from Melipilla to La Serena?

It takes approximately 4h 3m to get from Melipilla to La Serena, including transfers.

Where do I catch the Melipilla to La Serena bus from?

Melipilla to La Serena bus services, operated by Buses Melipilla Santiago, depart from Terminal de Buses de Melipilla station.

Where does the Melipilla to La Serena bus arrive?

Melipilla to La Serena bus services, operated by Buses Melipilla Santiago, arrive at Terminal San Borja station.

Can I drive from Melipilla to La Serena?

Yes, the driving distance between Melipilla to La Serena is 542 km. It takes approximately 5h 15m to drive from Melipilla to La Serena.

Where can I stay near La Serena?

There are 1445+ hotels available in La Serena. Prices start at $1 per night.
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