How to Travel from
Siena to Brindisi
by Plane, Bus, Route or Car
Schedule
Siena, Italy → Brindisi, Italy
All
08 août 2026
August 2026
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08 Aug, Sat
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Cheapest and Fastest Ways to Travel from Siena to Brindisi
Composite routes from Siena to Brindisi
Cheapest
7 h 38 min
Car
819 km.
from $45
Fastest
1 h 29 min
Plane
Other
9 h 16 min
Bus, Train
621 km.
from $5.43
4 h 42 min
Train, Plane
621 km.
from $103.33
6 h 1 min
Bus, Plane
621 km.
from $10.87
9 h 45 min
622 km.
from $168.39
13 h 30 min
622 km.
from $81.35
5 h 1 min
Bus, Train
621 km.
from $5.43
6 h 15 min
Bus, Train
621 km.
from $5.43
Route Navigator Siena - Brindisi
Get all the information you need right here
Continue
497 м
497 м
Continue onto Viale Don Giovanni Minzoni
Viale Don Giovanni Minzoni, 97 м
97 м
Turn right onto Via Lippo Memmi
Via Lippo Memmi, 272 м
272 м
Turn left onto Via Lorenzo Maitani
Via Lorenzo Maitani, 93 м
93 м
Turn left onto Via Lorenzo Maitani
Via Lorenzo Maitani, 83 м
83 м
Turn right onto Via Simone Martini
Via Simone Martini, 70 м
70 м
At roundabout, take exit 1 onto Via Simone Martini
Via Simone Martini, 1 km 639 м
1 km 639 м
At roundabout, take exit 3 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 47 м
1 km 47 м
At roundabout, take exit 2 onto Viale Pietro Toselli
Viale Pietro Toselli, 1 km 726 м
1 km 726 м
At roundabout, take exit 3 onto Strada Levante
Strada Levante, 1 km 529 м
1 km 529 м
At roundabout, take exit 2 onto Strada Levante
Strada Levante, 2 km 592 м
2 km 592 м
At roundabout, take exit 2 onto Raccordo Autostradale Siena-Bettolle
Raccordo Autostradale Siena-Bettolle, 43 km 237 м
43 km 237 м
Keep right onto Svincolo di Bettolle and drive toward Bettolle, A1 Firenze-Roma
Svincolo di Bettolle, Bettolle, A1 Firenze-Roma, 491 м
491 м
At roundabout, take exit 2 onto Casello di Valdichiana
Casello di Valdichiana, 271 м
271 м
Keep right onto Svincolo di Valdichiana and take A1 toward Roma
Svincolo di Valdichiana, Roma, A1, 315 km 487 м
315 km 487 м
Keep right and drive toward Caianello
Caianello, 1 km 854 м
1 km 854 м
Keep right onto Strada Statale 372 Telesina
Strada Statale 372 Telesina, 6 km 381 м
6 km 381 м
Keep right and drive toward Pietravairano
Pietravairano, 150 м
150 м
Keep left and drive toward Pietravairano
Pietravairano, 31 м
31 м
Turn right
215 м
215 м
Turn slight right onto Strada Statale 372 Telesina
Strada Statale 372 Telesina, 4 km 140 м
4 km 140 м
Keep right and drive toward Baia e Latina, Piedimonte
Baia e Latina, Piedimonte, 251 м
251 м
Keep left and drive toward Pietravairano, Alife
Pietravairano, Alife, 31 м
31 м
Turn right
239 м
239 м
Continue onto Strada Statale 372 Telesina
Strada Statale 372 Telesina, 59 km 850 м
59 km 850 м
Keep left onto Raccordo autostradale 9 di Benevento
Raccordo autostradale 9 di Benevento, 13 km 333 м
13 km 333 м
Keep right
103 km 172 м
103 km 172 м
Keep right onto Autostrada dei Due Mari and drive toward Bari
Autostrada dei Due Mari, Bari, 69 km 331 м
69 km 331 м
Keep right onto Raccordo A14-Tangenziale di Bari
Raccordo A14-Tangenziale di Bari, 191 м
191 м
Keep left onto Raccordo A14-Tangenziale di Bari
Raccordo A14-Tangenziale di Bari, 4 km 408 м
4 km 408 м
Keep right and drive toward Bari Centro, Taranto, Brindisi, Lecce, Sacrario Militare Caduti Oltremare
Bari Centro, Taranto, Brindisi, Lecce, Sacrario Militare Caduti Oltremare, 115 km 813 м
115 km 813 м
Keep right
377 м
377 м
At roundabout, take exit 4 onto Via Appia
Via Appia, 1 km 740 м
1 km 740 м
Turn sharp right onto Via San Giovanni Bosco
Via San Giovanni Bosco, 1 km 585 м
1 km 585 м
Turn left onto Viale Palmiro Togliatti
Viale Palmiro Togliatti, 255 м
255 м
Continue onto Viale Aldo Moro
Viale Aldo Moro, 494 м
494 м
Turn right onto Via Bruno Buozzi
Via Bruno Buozzi, 106 м
106 м
Arrive at destination
Transport providers
Airlines
Ryanair
Website:
ryanair.com/
Plane from Galileo Galilei International Airport to Papola
Ave. Duration:
1h 25m
Frequency:
Every day
Estimated price:
$26.68–$457.33
Plane from Bologna Guglielmo Marconi Airport to Papola
Ave. Duration:
1h 25m
Frequency:
Every day
Estimated price:
$25.41–$393.81
Plane from Leonardo Da Vinci–Fiumicino Airport to Papola
Ave. Duration:
1h 15m
Frequency:
Every day
Estimated price:
$15.24–$241.37
Swiss
Website:
swiss.com/
Plane from Florence Peretola Airport to Papola
Ave. Duration:
5h 5m
Frequency:
Friday and Sunday
Estimated price:
$381.11–$1,079.81
Alitalia
Website:
alitalia.com/
Plane from Florence Peretola Airport to Papola
Ave. Duration:
3h 28m
Frequency:
Every day
Estimated price:
$88.93–$368.41
Plane from Bologna Guglielmo Marconi Airport to Papola
Ave. Duration:
3h 20m
Frequency:
Every day
Estimated price:
$69.87–$279.48
Plane from Leonardo Da Vinci–Fiumicino Airport to Papola
Ave. Duration:
1h 10m
Frequency:
Every day
Estimated price:
$58.44–$368.41
Bus operators
FlixBus
Phone:
+49 30 300 137 300
Email:
service@flixbus.com
Website:
flixbus.com
Bus from Siena to Termoli
Ave. Duration:
7h 20m
Frequency:
Once daily
Estimated price:
$45.73–$63.52
Bus from Termoli to Brindisi
Ave. Duration:
5h 10m
Frequency:
6 times a week
Estimated price:
$34.30–$48.27
Marino Autolinee
Phone:
+39 080 3112335
Email:
info@marinobus.it
Website:
marinobus.it/
Bus from Siena Central Train Station to Brindisi
Ave. Duration:
10h 55m
Frequency:
Twice daily
Estimated price:
$63.52–$95.28
Autolinee Toscane - Linee Regionali
Phone:
+39 055 849 0505
Email:
servizioclienti@at-bus.it
Website:
at-bus.it/it
Bus from Siena-Via Tozzi to Firenze
Ave. Duration:
1h 15m
Frequency:
Hourly
Train operators
Trenitalia
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
4h 16m
Frequency:
Once daily
Estimated price:
$17.79–$59.71
Train from Siena to Firenze
Ave. Duration:
1h 34m
Frequency:
Hourly
Estimated price:
$8.26–$21.60
Train from Siena to Empoli
Ave. Duration:
1h 2m
Frequency:
Hourly
Estimated price:
$6.35–$15.24
Train from Empoli to Pisa
Ave. Duration:
30 min
Frequency:
Every 30 minutes
Estimated price:
$5.34–$10.80
Train from Firenze S.M.N. to Bologna
Ave. Duration:
1h 28m
Frequency:
Twice daily
Estimated price:
$7.62–$21.60
Trenitalia Frecce
Phone:
+39 06 68475475
Website:
trenitalia.com/en/frecce.html
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 37m
Frequency:
Every 30 minutes
Estimated price:
$26.68–$88.93
Train from Roma Termini to Brindisi
Ave. Duration:
5h 16m
Frequency:
5 times a day
Estimated price:
$45.73–$120.68
Train from Firenze S.M.N. to Brindisi
Ave. Duration:
7h 11m
Frequency:
Once daily
Estimated price:
$69.87–$215.96
Train from Firenze S.M.N. to Bologna
Ave. Duration:
38 min
Frequency:
Every 30 minutes
Estimated price:
$12.70–$55.90
ItaloTreno
Phone:
+39 06 8937 1892
Website:
italotreno.it/it
Train from Firenze S.M.N. to Roma
Ave. Duration:
1h 36m
Frequency:
Hourly
Estimated price:
$54.63–$76.22
Train from Firenze S.M.N. to Bologna
Ave. Duration:
39 min
Frequency:
Hourly
Estimated price:
$35.57–$44.46
Trenitalia Intercity
Phone:
+39 06 68475475
Website:
trenitalia.com/
Train from Firenze S.M.N. to Roma
Ave. Duration:
2h 35m
Frequency:
6 times a week
Estimated price:
$20.33–$29.22
Train from Firenze S.M.N. to Bologna
Ave. Duration:
1h 17m
Frequency:
Once daily
Estimated price:
$9.53–$12.70
Questions and Answers
What is the cheapest way to get from Siena to Brindisi?
The cheapest way to get from Siena to Brindisi is to bus which costs $54.35 - $81.52 and takes 10h 55m.
What is the fastest way to get from Siena to Brindisi?
The fastest way to get from Siena to Brindisi is to train and fly which takes 4h 42m and costs $38.04 - $271.74 .
Is there a direct bus between Siena and Brindisi?
Yes, there is a direct bus departing from Siena Central Train Station station and arriving at Brindisi Istituto Professionale Falcone. Services depart twice daily, and operate every day. The journey takes approximately 10h 55m.
Is there a direct train between Siena and Brindisi?
No, there is no direct train from Siena to Brindisi. However, there are services departing from Siena and arriving at Brindisi via Firenze S.M.N.. The journey, including transfers, takes approximately 9h 45m.
How far is it from Siena to Brindisi?
The distance between Siena and Brindisi is 919 km. The road distance is 819.1 km.
How do I travel from Siena to Brindisi without a car?
The best way to get from Siena to Brindisi without a car is to bus and train which takes 9h 16m and costs .
How long does it take to get from Siena to Brindisi?
It takes approximately 9h 16m to get from Siena to Brindisi, including transfers.
Where do I catch the Siena to Brindisi bus from?
Siena to Brindisi bus services, operated by Marino Autolinee, depart from Siena Central Train Station.
Where do I catch the Siena to Brindisi train from?
Siena to Brindisi train services, operated by Trenitalia, depart from Siena station.
Train or bus from Siena to Brindisi?
The best way to get from Siena to Brindisi is to bus which takes 10h 55m and costs $54.35 - $81.52 . Alternatively, you can train, which costs $65.22 - $206.52 and takes 9h 45m.
Where does the Siena to Brindisi bus arrive?
Siena to Brindisi bus services, operated by Marino Autolinee, arrive at Brindisi Istituto Professionale Falcone station.
Where does the Siena to Brindisi train arrive?
Siena to Brindisi train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Can I drive from Siena to Brindisi?
Yes, the driving distance between Siena to Brindisi is 819 km. It takes approximately 7h 37m to drive from Siena to Brindisi.
How do I get a train ticket from Siena to Brindisi?
Book your Siena to Brindisi train tickets online with Omio.
How do I get a bus ticket from Siena to Brindisi?
Book your Siena to Brindisi bus tickets online with Omio and Distribusion.
Where can I stay near Brindisi?
There are 842+ hotels available in Brindisi. Prices start at $37.11 per night.
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