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Cheapest
Best Offer!
Car
6 h 27 min
649 km.
from $35
Composite Route Car Only
Schedule
La Serena, Chile → Santa Cruz, Chile
All
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August 2026
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Cheapest and Fastest Ways to Travel from La Serena to Santa Cruz
Composite routes from La Serena to Santa Cruz
Cheapest
6 h 27 min
Car
Other
5 h 2 min
Plane, Bus
11 h 12 min
Bus, Train
9 h 25 min
11 h 56 min
Route Navigator La Serena - Santa Cruz
Get all the information you need right here
Continue onto Eduardo de la Barra
Eduardo de la Barra, 1 km 503 м
1 km 503 м
Turn left onto Pedro Pablo Muñoz
Pedro Pablo Muñoz, 70 м
70 м
Keep right
59 м
59 м
Turn right onto Avenida Francisco de Aguirre
Avenida Francisco de Aguirre, 264 м
264 м
Turn left onto Ruta 5 Norte and drive toward La Serena
Ruta 5 Norte, La Serena, 342 km 495 м
342 km 495 м
Keep left onto Ruta 5 Norte
Ruta 5 Norte, 17 km 540 м
17 km 540 м
Keep right and take F-62 toward La Calera, Artificio
La Calera, Artificio, F-62, 223 м
223 м
Turn slight right onto Manuel Rodríguez
Manuel Rodríguez, 226 м
226 м
Turn left onto Avenida Adrián
Avenida Adrián, 2 km 949 м
2 km 949 м
Turn right onto Caletera
Caletera, 488 м
488 м
Turn left onto La Feria
La Feria, 19 м
19 м
Turn right and take 60 toward Viña del Mar
Viña del Mar, 60, 40 km 87 м
40 km 87 м
Keep right and take F-560 toward Villa Alemana
Villa Alemana, F-560, 374 м
374 м
Keep left toward F-560
F-560, 26 м
26 м
Turn left onto Marga Marga
Marga Marga, 1 km 777 м
1 km 777 м
Continue onto Ruta F-560
Ruta F-560, 2 km 916 м
2 km 916 м
Turn left onto Ruta F-50
Ruta F-50, 25 km 950 м
25 km 950 м
Turn left onto Ruta F-844
Ruta F-844, 161 м
161 м
Keep left and take 68 toward Santiago
Santiago, 68, 7 km 301 м
7 km 301 м
Keep right and drive toward Casablanca, Lo Vásquez
Casablanca, Lo Vásquez, 1 km 509 м
1 km 509 м
Keep right and drive toward Casablanca
Casablanca, 47 м
47 м
Keep right onto Avenida Constitución
Avenida Constitución, 360 м
360 м
Keep left onto Avenida Arturo Prat
Avenida Arturo Prat, 2 km 516 м
2 km 516 м
Turn right onto Avenida Bernardo O'Higgins
Avenida Bernardo O'Higgins, 1 km 595 м
1 km 595 м
Turn left onto Avenida Diego Portales
Avenida Diego Portales, 93 м
93 м
Turn sharp right onto Melipilla
Melipilla, 167 м
167 м
Turn slight left onto Ruta F-74-G
Ruta F-74-G, 4 km 976 м
4 km 976 м
Keep right and drive toward Algarrobo
Algarrobo, 6 km 4 м
6 km 4 м
Keep right and take F-962-G, F-930 toward Lagunillas, San Antonio, Orrego Abajo
Lagunillas, San Antonio, Orrego Abajo, F-962-G, F-930, 226 м
226 м
Keep right and take F-962-G toward Lagunillas, San Antonio
Lagunillas, San Antonio, F-962-G, 108 м
108 м
Turn slight right
21 km 893 м
21 km 893 м
Keep right and drive toward Algarrobo
Algarrobo, 1 km 572 м
1 km 572 м
Turn sharp left onto Nuevo Camino Costero
Nuevo Camino Costero, 13 km 146 м
13 km 146 м
Keep right and drive toward Llolleo, Santo Domingo
Llolleo, Santo Domingo, 383 м
383 м
At roundabout, take exit 4 onto Avenida Chile
Avenida Chile, 3 km 544 м
3 km 544 м
Continue onto Ruta de la Fruta
Ruta de la Fruta, 2 km 515 м
2 km 515 м
Keep left
1 km 87 м
1 km 87 м
Turn right onto Las Higueras
Las Higueras, 450 м
450 м
Turn left onto Ruta de la Fruta
Ruta de la Fruta, 37 km 219 м
37 km 219 м
Keep right
389 м
389 м
At roundabout, take exit 1
340 м
340 м
Continue onto Ruta de la Fruta
Ruta de la Fruta, 44 km 734 м
44 km 734 м
Keep right
57 м
57 м
Turn slight right onto Ruta H-82-I
Ruta H-82-I, 18 km 12 м
18 km 12 м
Turn right onto Ruta H-82-I
Ruta H-82-I, 17 km 598 м
17 km 598 м
Turn sharp left onto Ruta H-82-I
Ruta H-82-I, 1 km 441 м
1 km 441 м
Continue onto Ruta I-340
Ruta I-340, 3 km 794 м
3 km 794 м
Turn left onto La Estampa
La Estampa, 8 km 12 м
8 km 12 м
Turn sharp left onto San Martín
San Martín, 233 м
233 м
Turn right onto Las Toscas
Las Toscas, 323 м
323 м
Turn left onto Avenida Diego Portales
Avenida Diego Portales, 7 м
7 м
Turn right onto Las Toscas
Las Toscas, 147 м
147 м
Turn right onto 21 de Mayo
21 de Mayo, 137 м
137 м
Arrive at destination
Transport providers
Airlines
JetSMART
Website:
jetsmart.com/
Plane from La Florida Airport to Comodoro
Ave. Duration:
58 min
Frequency:
Every day
Estimated price:
$23.91–$119.57
Sky Airline
Website:
skyairline.com/
Plane from La Florida Airport to Comodoro
Ave. Duration:
58 min
Frequency:
Every day
Estimated price:
$18.48–$97.83
LATAM Chile
Website:
latam.com/
Plane from La Florida Airport to Comodoro
Ave. Duration:
55 min
Frequency:
Every day
Estimated price:
$23.91–$108.70
Bus operators
Pullman Bus
Phone:
+56 600 600 0018
Email:
clientes@pullmanbus.cl
Website:
pullmanbus.cl
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
2h 50m
Frequency:
3 times a day
Estimated price:
$10.13–$27.17
Bus from Terminal Sur de Santiago to Peralillo
Ave. Duration:
3h 25m
Frequency:
Once daily
Estimated price:
$10.13–$27.17
Flixbus Chile
Website:
flixbus.com
Bus from Coquimbo to Santiago
Ave. Duration:
5h 10m
Frequency:
Once daily
Estimated price:
$7.61–$9.78
Turbus
Phone:
+56 22 822 7500
Email:
atencion_clientes@turbus.cl
Website:
turbus.cl/
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
6h 25m
Frequency:
Hourly
Estimated price:
$14.13–$38.04
Condor Bus
Phone:
+56 22 822 7528
Email:
clientescondor@condorbus.cl
Website:
condorbus.cl/
Bus from Terminal de Buses La Serena to Terminal
Ave. Duration:
6h 30m
Frequency:
4 times a day
Estimated price:
$14.13–$26.09
Andimar
Phone:
+56 22 683 8528
Email:
hola@andimar.cl
Website:
andimar.cl/
Bus from Terminal Sur de Santiago to Hospital
Ave. Duration:
2h 41m
Frequency:
Hourly
Estimated price:
$3.80–$10.33
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
2h 50m
Frequency:
Hourly
Estimated price:
$3.80–$10.33
TranSantin
Phone:
+56 2 2479 2925
Email:
servicioalcliente@transantin.cl
Website:
transantin.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
3h 20m
Frequency:
Hourly
Estimated price:
$6.52–$11.54
Bus from Terminal Sur de Santiago to Peralillo
Ave. Duration:
3h
Frequency:
Hourly
Estimated price:
$7.07–$11.96
Buses Romani
Phone:
+56 51 221 5300
Email:
atencionalcliente@romani.cl
Website:
busesromani.cl/
Bus from Terminal de Buses La Serena to Las
Ave. Duration:
7h 15m
Frequency:
Twice daily
Estimated price:
$15.22–$19.57
Expreso Santa Cruz
Email:
ayuda@pasajebus.com
Website:
expresosantacruz.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
3h
Frequency:
Hourly
Estimated price:
$4.97
Buses Jetsur
Phone:
+56 2 2666 5505
Email:
ayuda@recorrido.cl
Website:
jetsur.cl/
Bus from Terminal Sur de Santiago to Terminal
Ave. Duration:
3h 13m
Frequency:
3 times a day
Estimated price:
$10.13
Buses Peñablanca
Email:
busespenablanca@hotmail.com
Website:
facebook.com/profile.php?id=100063824239541
Bus from Terminal Sur de Santiago to Peralillo
Ave. Duration:
3h
Frequency:
Once a week
Estimated price:
$9.92
Train operators
EFE Trenes de Chile
Phone:
+56 22 585 5000
Email:
contacto@trencentral.cl
Website:
efe.cl/
Train from Estacion Central Alameda to San
Ave. Duration:
1h 46m
Frequency:
Every 3 hours
Estimated price:
$1.96–$3.80
Questions and Answers
What is the cheapest way to get from La Serena to Santa Cruz?
The cheapest way to get from La Serena to Santa Cruz is to bus and train which costs $11.96 - $46.74 and takes 11h 12m.
What is the fastest way to get from La Serena to Santa Cruz?
The fastest way to get from La Serena to Santa Cruz is to fly and bus which takes 5h 2m and costs $50 - $119.57 .
Is there a direct bus between La Serena and Santa Cruz?
No, there is no direct bus from La Serena to Santa Cruz. However, there are services departing from Terminal de Buses La Serena and arriving at Terminal de Buses Santa Cruz via Terminal Sur de Santiago. The journey, including transfers, takes approximately 9h 25m.
How far is it from La Serena to Santa Cruz?
The distance between La Serena and Santa Cruz is 594 km. The road distance is 649.6 km.
How do I travel from La Serena to Santa Cruz without a car?
The best way to get from La Serena to Santa Cruz without a car is to bus which takes 9h 25m and costs $18.48 - $65.22 .
How long does it take to get from La Serena to Santa Cruz?
It takes approximately 5h 2m to get from La Serena to Santa Cruz, including transfers.
Where do I catch the La Serena to Santa Cruz bus from?
La Serena to Santa Cruz bus services, operated by Turbus, depart from Terminal de Buses La Serena station.
Where does the La Serena to Santa Cruz bus arrive?
La Serena to Santa Cruz bus services, operated by Turbus, arrive at Terminal Alameda - Turbus station.
Can I drive from La Serena to Santa Cruz?
Yes, the driving distance between La Serena to Santa Cruz is 650 km. It takes approximately 6h 27m to drive from La Serena to Santa Cruz.
Where can I stay near Santa Cruz?
There are 58+ hotels available in Santa Cruz. Prices start at $72.84 per night.
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